منابع مشابه
Alternative Cell Death Pathways and Cell Metabolism
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revi...
متن کاملPathways to cell death in hyperoxia.
(CHEST 1999; 116:64S–67S) A widely held opinion about cell death is that apoptosis follows a series of events that are genetically programmed and necrosis does not. This simple-minded notion is partially due to the problem that most thinking about cell death is dichotomous: cell death is either apoptosis or necrosis. Thus, necrosis is currently the term used to describe slow death associated wi...
متن کاملMajor cell death pathways at a glance.
Cell death is a crucial process during development, homeostasis and immune regulation of multicellular organisms, and its dysregulation is associated with numerous pathologies. Cell death is often induced upon pathogen infection as part of the defense mechanism, and pathogens have evolved strategies to modulate host cell death. In this review, we will discuss the molecular mechanisms and physio...
متن کاملRetrograde axonal transport: pathways to cell death?
Active transport along the axon is crucial to the neuron. Motor-driven transport supplies the distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded proteins. Microtubule motors also drive long-distance signaling along the axon via signaling endosomes. Although positive signaling initiated by neurotrophic factors has been well-studied, recent research has foc...
متن کاملA multiplicity of cell death pathways
Introduction In an adult human, millions of cells die each second as a result of normal development as well as loss associated with pathology. For years, it has been widely assumed that this cell death occurs primarily through one mechanism—apoptosis—at least in physiological circumstances (Lockshin & Zakeri, 2001; Horvitz, 2003). The 2007 Keystone Symposium on Apoptosis and Non-Apoptotic Cell ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2013
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2013.09.016